Base de dados : HANSEN
Pesquisa : GENES DE IMUNOGLOBULINAS [Descritor de assunto]
Referências encontradas : 2 [refinar]
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Id:22674
Autor:Bleharski, Joshua R; Li, Huiying; Meinken, Cristoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L
Título:Use of genetic profiling in leprosy to discriminate clinical forms of the disease
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Fonte:s.l; s.n; 2003. 4 p. .
Resumo:Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU).
Descritores:Algoritmos
Análise por Conglomerados
Contagem de Colônia Microbiana
Citocinas/GE/ME
Perfilação da Expressão Gênica/*
Regulação da Expressão Gênica/*
Genes de Imunoglobulinas
Imunidade Celular
Imunidade Natural
Hanseníase Virchowiana/*CL/*GE/IM/PP
Hanseníase Tuberculóide/*CL/*GE/IM/PP
Macrófagos Alveolares/MI
Glicoproteínas de Membrana/IM
Mycobacterium tuberculosis/GD/IM
Análise de Sequência com Séries de Oligonucleotídeos
Reação em Cadeia da Polimerase
Análise de Componente Principal
Receptores da Superfície Celular/IM
Receptores Imunológicos/GE/ME
Limites:Humano
Support, Non-U.S. Gov't
Support, U.S. Gov't, P.H.S.
Regulação para Cima
Localização:BR191.1; 09174/s


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Id:18504
Autor:Bleharski, Joshua R; Li, Huiying; Meinken, Christoph; Graeber, Thomas G; Ochoa, Maria-Teresa; Yamamura, Masahiro; Burdick, Anne; Sarno, Euzenir N; Wagner, Manfred; Röllinghoff, Martin; Rea, Thomas H; Colonna, Marco; Stenger, Steffen; Bloom, Barry R; Eisenberg, David; Modlin, Robert L
Título:Use of genetic profiling in leprosy to discriminate clinical forms of the disease
..-
Fonte:s.l; s.n; Sep. 2003. 4 p. graf.
Resumo:Leprosy presents as a clinical and immunological spectrum of disease. With the use of gene expression profiling, we observed that a distinction in gene expression correlates with and accurately classifies the clinical form of the disease. Genes belonging to the leukocyte immunoglobulin-like receptor (LIR) family were significantly up-regulated in lesions of lepromatous patients suffering from the disseminated form of the infection. In functional studies, LIR-7 suppressed innate host defense mechanisms by shifting monocyte production from interleukin-12 toward interleukin-10 and by blocking antimicrobial activity triggered by Toll-like receptors. Gene expression profiles may be useful in defining clinical forms of disease and providing insights into the regulation of immune responses to pathogens. (AU).
Descritores:HANSENIASE VIRCHOWIANA/clas
HANSENIASE VIRCHOWIANA/genet
HANSENIASE VIRCHOWIANA/imunol
HANSENIASE VIRCHOWIANA/fisiopatol
HANSENIASE TUBERCULOIDE/clas
HANSENIASE TUBERCULOIDE/genet
HANSENIASE TUBERCULOIDE/imunol
HANSENIASE TUBERCULOIDE/fisiopatol
CITOCINAS/genet
CITOCINAS/metab
PERFILACAO DA EXPRESSÃO GÊNICA
ANALISE POR CONGLOMERADOS
CONTAGEM DE COLÔNIA MICROBIANA
REGULACAO DA EXPRESSÃO GÊNICA
IMUNIDADE CELULAR
IMUNIDADE NATURAL
MACROFAGOS ALVEOLARES/microbiol
GLICOPROTEINAS DE MEMBRANA/imunol
MYCOBACTERIUM TUBERCULOSIS/cresc
MYCOBACTERIUM TUBERCULOSIS/imunol
REACAO EM CADEIA DA POLIMERASE
RECEPTORES IMUNOLOGICOS/genet
RECEPTORES IMUNOLOGICOS/metab
RECEPTORES DA SUPERFICIE CELULAR/imunol
REGULACAO PARA CIMA
 Análise de Componente Principal
 ALGORITMOS
 GENES DE IMUNOGLOBULINAS
 ANALISE DE SEQUÊNCIA COM SERIES DE OLIGONUCLEOTIDIOS
Limites:SUPPORT, NON-U.S. GOV'T
HUMANO
SUPPORT, U.S. GOV'T, P.H.S.
Meio Eletrônico: - .
Localização:BR191.1; 09142/s; BR191.1; 09145/s



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